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Slavin, M.B.; Memme, J.M.; Oliveira, A.N.; Moradi, N and D.A. Hood. Regulating networks coordinating mitochondrial quality control in skeletal muscle. Cell Physiology. doi:10.1152/ajpcell.00065.2022. 03/30/2022.

Triolo, M., A.N. Oliveira, R. Kumari and D.A. Hood. The influence of age, sex and exercise on autophagy, mitophagy and lysosome biogenesis in skeletal muscle. Skelet. Muscle doi:10.1186/s13395-022-00296-7.

Triolo, M, M. Slavin, N. Moradi and D.A. Hood. Time-dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation-induced disuse. J. Physiol. doi: 10.1113/JP282173, 2022.

Memme, J.M., A.N. Oliveira and D. A. Hood.  The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse. Autophagy Rep. (in press, 2022)

Richards, B.J., M. Slavin, A.N. Oliveira, V.C. Sanfrancesco and D.A. Hood. Mitochondrial protein import and UPRmt in skeletal muscle remodeling and adaptation. Semin. Cell Develop. Biol., 2022.

Memme, J.M., A.N. Oliveira and D. A. Hood.  p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse. J. Biol. Chem. 298: 101540-101558, 2022.

Oliveira, A.N., B. Richards and D.A. Hood. Measurement of protein import capacity of skeletal muscle mitochondria. J Vis Exp. 179. doi: 10.3791/63055, 2022.


Triolo, M. and D.A. Hood. Manifestations of age on autophagy, mitophagy and lysosomes in skeletal muscle. Cells 10(5):1054. doi: 10.3390/cells10051054, 2021.

Memme, J.M, M. Slavin, N. Moradi and D.A. Hood. Mitochondrial Bioenergetics and Turnover During Chronic Muscle Disuse. International Journal of Molecular Sciences 22(10):5179. doi: 10.3390/ijms22105179, 2021.

Bonafiglia J.T., H. Islam, N. Preobrazenski, A. Ma, M. Deschenes, A.T. Erlich, J. Quadrilatero, D. A. Hood and B.J. Gurd. Examining interindividual differences in select muscle and whole-body adaptations to continuous endurance trainingExp Physiol. doi: 10.1113/EP089421,2021.

Picca, A., S.K. Saini, R.T. Mankowski, G. Kamenov, S.D. Anton, T.M. Manini, T.W. Buford, S.E. Wohlgemuth, R. Xiao, R. Calvani, H.J. Coelho-Junior, F. Landi, R. Bernabei, D.A. Hood, E. Marzetti and C. Leeuwenburgh. Altered expression of mitoferrin and frataxin, larger labile iron pool and greater mitochondrial DNA damage in skeletal muscle of older adults. Cells. 9:2579. doi: 10.3390/cells 9122579, 2021.

Oliveira, A.N., B. Yanagawa, S. Verma and D.A. Hood.  Blunted stress response with age in right atrial tissue following ischemia-reperfusion. J. Card Surg. doi: 10.1111/jocs.15807, 2021.

Cheema, N., J.M. Cameron and D.A. Hood.  Mitochondrial dysfunction in fibroblasts with mtDNA defects is attenuated with rapamycin treatment. Am. J. Physiol. Cell Physiol. 321:C176-C186, 2021.

Oliveira, A.N., B. Richards, M. Slavin and D.A. Hood.  Exercise is mitochondrial medicine for muscle. Exerc. Sport Sci. Reviews 49:67-76, 2021.

Memme, J.M. and D.A. Hood. Molecular basis for the therapeutic effects of exercise on mitochondrial defects. Frontiers Physiol.  11:615038. doi: 10.3389/fphys.2020.6150382021, 2021.


Zhang Y, Oliveira AN, Hood DAThe intersection of exercise and aging on mitochondrial protein quality controlExp Gerontol. 2020;131:110824. doi:10.1016/j.exger.2019.110824

Islam H, Hood DA, Gurd BJ. Looking beyond PGC-1α: emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds. Appl Physiol Nutr Metab. 2020;45(1):11-23. doi:10.1139/apnm-2019-0069


Erlich AT, Hood DA. Mitophagy regulation in skeletal muscle: Effect of endurance exercise and age. Journal of Science in Sport and Exercise. Accepted September 25, 2019

Oliveira AN, Hood DA. Exercise is mitochondrial medicine for muscle. Sports Medicine and Health Science. 1:000-000, 2019

Memme JM, Erlich AT, Phukan G, Hood DAExercise and mitochondria health. J Physiol. 2019 Nov 1. doi: 10.1113/JP278853. [Epub ahead of print]

Triolo M, Hood DAMitochondrial breakdown in skeletal muscle and the emerging role of the lysosomes. Arch Biochem Biophys. 661:66-73, 2019

Hood DA, Memme JM, Oliveira AN, Triolo M. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Annu Rev Physiol. 81:19-4, 2019

Kim Y, Triolo M, Erlich AT, Hood DARegulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pfluger's Arch. 471:431-440, 2019



Chen CCW, Erlich AT, Crilly MJ, Hood DA. Parkin is required for exercise-induced mitophagy in muscle: impact of aging. Am J Physiol Endocrinol Metab. 315(3):E404-E415, 2018

Carter HN, Kim Y, Erlich AT, Zarrin-Khat D, Hood DA. Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J Physiol. 596(16):3567-3584, 2018

Chen CCW, Erlich AT, Hood DA. Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle. Skelet Muscle. 2018 Mar 17;8(1):10. doi: 10.1186/s13395-018-0157-y.

Carter HN, Pauly M, Tryon LD, Hood DA. Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle.J Appl Physiol (1985). 124(6):1605-1615, 2018

Kim Y, Memme JM, and Hood DA. Application of Chronic Stimulation to Study Contractile Activity-Induced Rat Skeletal Muscle Phenotypic Adaptations.  Jove. e56827, 2018.

Beyfuss K, and Hood DA. A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Reports. 23(1): 100-117, 2018.

Erlich AT, Brownlee DM, Beyfuss K, Hood DA. Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner. Am J Physiol Cell Physiol. l 314: C62–C72, 2018.


Kim Y, Triolo M, and Hood DA. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle. Oxid Med Cell Longev. 2017:3165396, 2017.

Mesbah Moosavi Z.S and Hood DA. The unfolded protein response in relation to mitochondrial biogenesis in skeletal muscle cells. Am J Physiol Cell Physiol. 312(5):C583-C594, 2017.


Hornberger T.A., H.N. Carter, D.A. Hood, V.C. Figueiredo, E.E. Dupont-Versteegden, C.A. Peterson, J.J. McCarthy, D.M. Camera, J.A. Hawley, T. Chaillou, A.J. Cheng, G.A. Nader, R.C. Wust, R.H. Houtkooper. Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. J. Appl. Physiol. 121:597-600, 2016.

Crilly, M.J.,  Tryon, L.D.,  Erlich A.T. and Hood, D.A. The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J. Appl. Physiol. 121(3):730-40, 2016.

Hood, D.A., L.D. Tryon, H.N. Carter, Y. Kim and C.C.W. Chen. Unraveling the mechanisms regulating muscle mitochondrial biogenesis. Biochem. J. 473(15):2295-314, 2016.

Erlich, A.T., L.D. Tryon, M.J. Crilly, J. M. Memme, Z. S. Mesbah Moosavi, A.N. Oliveira, K. Beyfuss and D.A. Hood. Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis. Integr. Med. Res. 5(3):187-197, 2016.

Memme JM, Oliveira AN, Hood DA. The chronology of UPR activation in skeletal muscle adaptations to chronic contractile activityAm J Physiol Cell Physiol. 310: C1024-C1036, 2016.

Klionsky, D.J., Abdelmohsen K., Hood, D.A. et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy 12:1-222, 2016.

Vainshtein A, Hood DA. The regulation of autophagy during exercise in skeletal muscle. J Appl Physiol (1985). 2016 Mar 15;120(6):664-73.


Zhang, Y., L.D. Tryon and D.A. Hood. Absence of Bax and Bak: Implications for autophagy and alternative mitochondrial functions. In Hayat, M.A. (Ed.) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging: Vol. 9. Human Diseases and Autophagosome. Elsevier, 2016, Chapter 7, pp. 155-164.

Hood, D.A., L.D. Tryon, A. Vainshtein, J. Memme, C. Chen, M. Pauly, M.J. Crilly and H. Carter, Exercise and the Regulation of Mitochondrial Turnover. I n: Claude Bouchard (Ed.), Progress in Molecular Biology and Translational Science, 135: 99-127, 2015.

Tryon, L.D., M.J. Crilly and D.A. Hood.  Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscleAm. J. Physiol. Cell Physiol. 2015 309: C228-38, 2015

Collu-Marchese, M., M. Shuen, M. Pauly, A. Saleem and D.A. Hood. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiationBioscience Reports 35: e00221, DOI: 10.1042/BSR20150073, 2015.

Carter, H.N., C.C.W. Chen and D.A. Hood. Mitochondria, Muscle Health and Exercise with Advancing Age. Physiology 30:208-223, 2015.

Vainshtein, A., E.M. Desjardins, A. Armani, M. Sandri, and D.A. Hood. PGC-1α modulates denervation-induced mitophagy in skeletal muscle. Skeletal Muscle 5:9, 2015.

Vainshtein, A., L.D. Tryon, M. Pauly, and D.A. Hood. The role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscleAm. J. Physiol. Cell Physiol. 308:C710-C719, 2015.

Saleem, A., S. Iqbal, Y. Zhang and D.A. Hood.  Effect of p53 on mitochondrial morphology, import and assembly in skeletal muscle. Am. J. Physiol. Cell Physiol. (in press), 2015.

Tryon, L.D., A. Vainshtein, J.M. Memme, M.J. Crilly and D.A. Hood. Relationship between the regulation of muscle atrophy and mitochondrial turnover during chronic disuseIntegr Med Res (in press, 2015).

Iqbal, S., and D. A. Hood. The role of mitochondrial fusion and fission in skeletal muscle function and dysfunction. Front Biosci. 20(1):157-172, 2015.

Saleem A, Iqbal S, Zhang Y, Hood DA. Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscleAm J Physiol Cell Physiol. 2015 Feb 15;308(4):C319-29.


Joseph AM, Hood DA. Relationships between exercise, mitochondrial biogenesis and type 2 diabetes. Med Sport Sci. 60:48-61, 2014.

Iqbal S, Hood DA. Cytoskeletal regulation of mitochondrial movements in myoblasts. Cytoskeleton (Hoboken). 71(10):564-72, 2014.

Zhang, Y., G. Uguccioni, V. Ljubicic, I. Irrcher, S. Iqbal, K. Singh, S. Ding, and D.A. Hood.  Multiple signaling pathways regulate contractile activity-mediated PGC-1α gene expression and activity in skeletal muscle cells. Physiol Rep.  19: e12008, 2014.

Iqbal, S. and D.A. Hood. Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts. Am. J. Physiol. Cell Physiol. 306: C1176-83, 2014.

Saleem, A., H.N. Carter and D.A. Hood.  p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am. J. Physiol. Cell Physiol. 306: C241-C249, 2014.


Zhang, Y., Iqbal S., O'Leary, M.F., Menzies, K.J., Saleem, A., Ding, S. and D.A. Hood. Altered mitochondrial morphology and defective protein import reveals novel roles for Bax and/or Bak in skeletal muscle. Am J Physiol Cell Physiol. 305: C502-C511, 2013.

Saleem A., and D.A. Hood. Acute exercise induces p53 translocation to the mitochondria and promotes a p53-Tfam-mtDNA complex in skeletal muscle. J Physiol (Lond). 591: 3625-36, 2013.

Iqbal, S. O. Ostojic, K. Singh, A.-M. Joseph, and D.A. Hood. Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuseMuscle Nerve 48: 963-70, 2013.

Pastore, S. and D.A. Hood. Endurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant miceJ. Appl. Physiol. 114: 1076-84, 2013.

Menzies, K.J., K. Singh, A. Saleem and D.A. Hood.  Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesisJ. Biol. Chem. 288: 6968-79, 2013.

Ostojic, O., M.F. O'Leary, K. Singh, K.J. Menzies, A. Vainshtein and D.A. Hood. The effects of chronic muscle use and disuse on cardiolipin metabolismJ. Appl. Physiol. 114: 444-452, 2013.

O'Leary, M.F., A. Vainshtein, S. Iqbal, O. Ostojic and D.A. Hood. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. Am J Physiol Cell Physiol. 304: C422-30, 2013.

Hood, D.A. and S. Iqbal.  Muscle mitochondrial ultrastructure: new insights into morphological divergences. J. Appl. Physiol. 114:159-60, 2013.

Hood, D.A., A. Saleem, H. Carter, A. Vainshtein, O. Ostojic, and S. Iqbal.  Molecular basis of exercise training adaptations in skeletal muscle.  In: MacIntosh, B.M. (Ed.).  Exercise Physiology in Canada. Toronto: McGraw-Hill, Chpt. 14 (in review).


Klionsky, D.J., Abdalla, F.C. Hood, D.A. et al.  Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8:445-544, 2012.

Carter, H.N. and D.A. Hood.  Contractile activity-induced mitochondrial biogenesis and mTORC1Am. J. Physiol. Cell Physiol. 303: C540-C547, 2012.

D’souza, D., R. Lai, M. Shuen and D.A. Hood. mRNA Stability as a Function of Striated Muscle Oxidative CapacityAm. J. Physiol. Regul. Integ. Comp. Physiol. 303:R408-R417, 2012.

O’Leary, M.F.N., A. Vainshtein, H.N. Carter, Y. Zhang and D.A. Hood.  Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animalsAm. J. Physiol. Cell Physiol. 303: C447-C454, 2012.

Menzies, K.J., B. Chabi, D.A. Hood, S. Schenk, A. Philp, V.A. Braga and D.D. Guimaraes. Commentaries on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?  J. Appl. Physiol. 112:929-30, 2012.

Joseph, A.M., D.R. Joanisse, R.G. Baillot, and D.A. Hood.  Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventionsExp Diabetes Res. doi:  10.1155/2012/642038 2012.

Joseph, A.M., and D.A. Hood.  Plasticity of TOM complex assembly in skeletal muscle mitochondria in response to chronic contractile activity.  Mitochondrion. 12:305-12, 2012.

Menzies, K. and D.A. Hood.  The role of SirT1 in muscle mitochondrial turnoverMitochondrion  12: 5-13, 2012.

Hood, D.A., M.F.N. O'Leary, G. Uguccioni and I. Irrcher.  Metabolic Systems: Mitochondrial Mitochondrial Biogenesis induced by Endurance Training. In: Farrell, P.A., M.J. Joyner and V.J. Caiozzo (Eds). ACSM Graduate Textbook of Exercise Physiology.  Baltimore: Lippincott, Williams and Wilkens Chapter 18, pp. 447-465, 2012.


Saleem A., H.N. Carter, S. Iqbal, and D.A. Hood.  Role of p53 within the regulatory network controlling muscle mitochondrial biogenesisExerc Sport Sci Rev. 39:199-205, 2011.

Vainshtein, A., L. Kazak and D.A. Hood.  Effects of endurance training on apoptotic susceptibility in striated muscleJ. Appl. Physiol. 110: 1638-45, 2011.

Nguyen, L M.-D. and D.A. Hood. Contractile activity-induced gene expression in fast-and slow-twitch muscleAppl. Physiol. Nutr. Metab. 36:233-41, 2011.

Hood, D.A., G. Uguccioni, A. Vainshtein and D. D’souza.  Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle: implications for health and diseaseCompr. Physiol. 1: 1119-1134, 2011 (July).

Uguccioni, G. and D.A. Hood.  The importance of PGC-1α in contractile activity-induced mitochondrial adaptations. Am. J. Physiol. Endocrinol. Metab. 300:E361-E371, 2011.

Singh, K. and D.A. Hood.  Effect of denervation-induced muscle disuse on mitochondrial protein import.  Am. J. Physiol. Cell Physiol. 300: C138-145, 2011.

Hood, D.A. and K. Singh. Mitochondrial Biogenesis. In: Mooren, F.C. and J.S. Skinner (Eds) Encyclopedia of Exercise Medicine and Disease. Heidelburg: Springer Verlag,, 2011.

Saleem, A., L. Kazak, M.O’Leary, and D.A. Hood. Muscle. In: J.C. Reed and D. Green D (Eds.) Apoptosis: Physiology and Pathology of Cell Death New York: Cambridge University Press, pp. 313-322, 2011.


Uguccioni, G., D. D’souza and D.A. Hood.  Regulation of PPARγ coactivator-1α function and expression in muscle: effect of exercisePPAR Res. pii: 937123. 2010.

Lai, R.Y. V. Ljubicic, D. D’souza and D.A. Hood.  Effect of chronic contractile activity on mRNA stability in skeletal muscleAm. J. Physiol. Cell Physiol. 299:C155-63, 2010.

Joseph, A.M., V. Ljubicic, P.J. Adhihetty, and D.A. Hood. Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activityAm. J. Physiol. Cell Physiol. 298: C1308-C1314, 2010.

Huang J.H., A.-M. Joseph, V. Ljubicic, S. Iqbal, and D.A. Hood. Effect of age on the processing and import of matrix-destined mitochondrial proteins in skeletal muscleJ. Gerontol. A Biol. Sci. Med. Sci. 65:138-46, 2010.

Ljubicic, V., A.-M. Joseph, A. Saleem, G. Uguccioni, M. Collu-Marchese, R.Y.J. Lai, L.M.-D. Nguyen, and D.A. Hood.  Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and agingBiochim Biophys Acta. 1800:223-34, 2010.

Ljubicic, V., K.J. Menzies and D.A.Hood. Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscleMech Ageing Dev. 131:79-88, 2010.

Hood D.A. Physical activity and skeletal muscle biology. In: Bouchard, C. and P. Katzmarzyk (Eds.) Advances in Physical Activity and Obesity Champaign, IL: Human Kinetics Pubs. Chpt. 42, pp. 170-173, 2010.


Ljubicic, V. A.-M. Joseph, P.J. Adhihetty, J. H. Huang, A. Saleem, G. Uguccioni, and D.A. Hood.  Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle.  Aging. 1: 818-830, 2009.

Chabi B., P.J. Adhihetty, M.F. O'Leary, K.J. Menzies, D.A. Hood.  Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse.  J Appl Physiol. 107: 1730-1735, 2009.

Ljubicic V, Hood DA.  Specific attenuation of protein kinase activation in muscle with a high mitochondrial content.  Am J Physiol Endocrinol Metab. 297:E749-58, 2009.

Ljubicic V. and D.A. Hood. Diminished contraction-induced intracellular signaling towards mitochondrial biogenesis in aged skeletal muscle. Aging Cell 8: 394-404, 2009.

Adhihetty P.J., G. Uguccioni, L. Leick, J. Hidalgo, H. Pilegaard and D.A. Hood. The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. Am J Physiol Cell Physiol. 297: C217-25, 2009.

Hood, D.A. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Appl. Physiol. Nutr. Metab. 34: 465-72, 2009.

Saleem, A., P.J. Adhihetty and D.A. Hood.  Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle.  Physiol. Genomics.  37:58-66, 2009.

Menzies, K.J., B. H. Robinson and D.A. Hood.  Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects.  Am. J. Physiol. Cell Physiol. 296:C355-62, 2009.

Irrcher, I. V. Ljubicic and D.A. Hood.  Interactions between reactive oxygen species and AMP kinase activity in the regulation of PGC-1α expression in skeletal muscle cells.  Am. J. Physiol. Cell Physiol. 296: C116-C123, 2009.

O’Leary, M.F.N. and D.A. Hood.  Denervation-induced oxidative stress and autophagy signaling in muscle.  Autophagy, 5:230-1, 2009.

Huang, J and D.A. Hood.  Age-associated mitochondrial dysfunction in skeletal muscle: contributing factors and suggestions for long-term interventions.  IUBMB Life 61:201-214, 2009.

Joseph, A.-M. V. Ljubicic, K. Menzies, L. Kazak, G. Uguccioni, and D.A. Hood Mitochondrial biogenesis in health and disease-influence of stress stimuli. In: J. Magalhaes and A. Ascensao (Eds.) Muscle Plasticity: Advances in Physiological and Biochemical Research. Kerala: The Research Signpost/ Transworld Research Network, pp. 151-171, 2009.

Irrcher, I, Ljubicic, V., Kirwan, A. and D.A. Hood, AMP-activated protein kinase-regulated activation of the PGC-1a promoter in skeletal muscle cells. PLoS One, 3: e3614, 2008.

Ljubicic, V. and D.A. Hood. Kinase-specific responsiveness to incremental contractile activity in skeletal muscle with low and high mitochondrial content. Am. J. Physiol. Endocrin. Metab. 295: E195-E204, 2008.

O’Leary, M.F.N. and D.A. Hood. The effect of prior chronic contractile activity on mitochondrial function and apoptotic protein expression in denervated muscle. J. Appl. Physiol. 105: 114-120, 2008.

Kavasis, A.N, J..M. McLung, D.A. Hood and S.K. Powers.  Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli.  Am. J. Physiol. (Heart Circul.) 294: H928-H935, 2008.

Adhihetty, P.J., M.F.N. O’Leary and D.A. Hood.  Mitochondria in skeletal muscle: adaptable rheostats of apoptotic susceptibility.  Exerc. Sport Sci. Rev. 36:116-121, 2008.

Chabi, B., V. Ljubicic, K. J. Menzies, J.H. Huang, A.Saleem and D.A. Hood. Mitochondrial function and apoptotic susceptibility in aging skeletal muscle.  Aging Cell 7:2-12, 2008.

Irrcher, I., D.R. Walkinshaw, T.E. Sheehan, and D.A. Hood.  Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo.  J. Appl. Physiol. 104: 178-185, 2008.

Hood, D.A. (Editor) Mitochondrial Biogenesis. Henry Stewart Talks: Biomedical and Life Science Collection, 2008.

Yoshida, Y., G.P. Holloway, V. Ljubicic, H. Hatta, L.L. Spriet,  D.A. Hood, and A. Bonen.  Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle.  J. Physiol. 582: 1317-1335, 2007.

Hood, D.A. and A. Saleem. Exercise-induced mitochondrial biogenesis in skeletal muscle.  Nutr. Metab. Cardiov. Disease, 17: 332-337, 2007.

Adhihetty P.J., T. Taivassalo, R. Haller, D. Walkinshaw and D.A. Hood.  The effect of endurance training on the expression of mitochondrial biogenesis- and apoptosis- related proteins in skeletal muscle of patients with mtDNA defects. Am. J. Physiol. (Endocrinology Metabolism), 293: E672-E680, 2007.

Adhihetty, P.J., M.F.N. O’Leary, B. Chabi, K.L. Wicks and D.A. Hood. Effect of chronic denervation on mitochondrially-mediated apoptosis in skeletal muscle. J. Appl. Physiol 102:1143-1151, 2007.

Adhihetty P.J., V. Ljubicic, K. Menzies, and D.A. Hood.  The effect of chronic contractile activity  on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle. Am. J. Physiol. (Endocrinology Metabolism) 292: E748-E755, 2007.

Stocchi, V., P. DeFeo and D.A. Hood (Editors). Role of Physical Exercise in Preventing Disease and Improving the Quality of Life. Milan: Springer-Verlag Italia, 2007.

Hood, D.A., B. Chabi, K. Menzies, M. O’Leary and D. Walkinshaw. Exercise-induced mitochondrial biogenesis in skeletal muscle.  In: Stocchi, V., P. DeFeo and D.A. Hood (Editors). Role of Physical Exercise in Preventing Disease and Improving the Quality of Life. Milan:  Springer-Verlag Italia, pp. 37-60, 2007.

Joseph, A.-M., H. Pilegaard, A. Litvintsev, L. Leick and D.A. Hood.  Control of gene expression  and mitochondrial biogenesis in the muscular adaptation to endurance exercise.  Essays Biochem.  42: 13-29, 2006.

Hood, D.A., I, Irrcher, V. Ljubicic and A.-M. Joseph.  Coordination of metabolic plasticity in skeletal muscle.  J. Exp. Biol. 209: 2265-2275, 2006.

Hood, D.A. and T.J. Hawke.  Skeletal muscle stem cells: a symposium.  Appl. Physiol. Nutr. Metab. 31: 771-772, 2006.

Hood, D.A., and I. Irrcher.  Metabolic Systems: Muscle Mitochondrial Biogenesis. Tipton, CM and C.A. Tate (Eds). ACSM Graduate Textbook of Exercise Physiology.  Baltimore: Lippincott, Williams and Wilkens pp. 437-452, 2006.

Chabi, B., P.J. Adhihetty, V. Ljubicic and D.A. Hood. How is mitochondrial biogenesis affected in mitochondrial disease? Med. Sci. Sport Exerc. 37:2102-2110, 2005.

Ljubicic, V., P.J. Adhihetty and D.A. Hood. Application of animal models: chronic electrical stimulation-induced contractile activity. Can. J. Appl. Physiol. 30:625-643, 2005.

Adhihetty, P.J., V. Ljubicic, K.J. Menzies and D.A. Hood.   Differential susceptibility of SS and IMF mitochondria to apoptotic stimuli.  Am. J. Physiol. Cell Physiol. 289: C994-C1001, 2005.

Hood, D.A. and A-M Joseph. Mechanisms of mitochondrial disease and the role of exercise: a symposium. Med. Sci. Sport Exerc. 37: 2084-2085, 2005.


Irrcher, I. and D.A. Hood. Regulation of Egr-1, SRF and Sp1 mRNA expression in contracting skeletal muscle cells. J Appl Physiol. 97:2207-2213, 2004.

Ljubicic, V., P.J. Adhihetty, and D.A. Hood.  Role of UCP3 in state 4 respiration during contractile activity-induced mitochondrial biogenesis.  J. Appl. Physiol. 97:976-83, 2004.

Sheehan, T.E., P.A. Kumar, and D.A. Hood.  Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone.  Am. J. Physiol. Endocrinol. Metab. 286: E968-E974, 2004.

Hood, D.A., and A.-M. Joseph. Mitochondrial assembly: protein import.  Proc. Nutr. Soc. 63:1-8, 2004.

Freyssenet, D., I. Irrcher, M.K. Connor, M. Di Carlo, and D.A. Hood. Calcium-regulated changes in mitochondrial phenotype in skeletal muscle cells.  Am. J. Physiol. Cell Physiol. 286: C1053-C1061, 2004.

Joseph, A.M., A.A. Rungi, B.H. Robinson, and D.A. Hood.  Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects.  Am. J. Physiol. Cell Physiol.  286: C867-C875, 2004.

Binas B, X.X. Han, E. Erol, J.J. Luiken, J.F. Glatz, D.J. Dyck, R. Mortazavi, P.J. Adhihetty, D.A. Hood, and A. Bonen. A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism. Am. J. Physiol. Endocrinol. Metab. 285:E481-9, 2003.

Irrcher, I., P.J. Adhihetty, A-M. Joseph, V. Ljubicic and D.A. Hood.  Regulation of Mitochondrial Biogenesis in Muscle by Endurance Exercise.  Sports Medicine.  33: 783-793, 2003.

Adhihetty, P. and D.A. Hood.  Mechanisms of Apoptosis in Skeletal Muscle.  Basic Appl. Myol.13 (4): 171-179, 2003.

Irrcher, I., P.J. Adhihetty, T. Sheehan, A-M. Joseph and D.A. Hood.  PPARγ coactivator-1α expression during thyroid hormone-and contractile activity-induced mitochondrial adaptations.  Am. J. Physiol.  284: C1669-C1677, 2003.

Adhihetty, P.J., I. Irrcher, A.-M. Joseph, V. Ljubicic and D.A. Hood. Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp. Physiol.  88: 99-107, 2003.

Moyes, C.D. and D.A. Hood.  Origins and consequences of mitochondrial variation. Ann. Rev. Physiol.  65: 177-201, 2003.

Colavecchia, M., L.N. Christie, Y.S. Kanwar, and D.A. Hood.  Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway.  Am. J. Physiol. 284: E29-E35, 2003.

Hood, D.A., P. Adhihetty, M. Colavecchia, J.W. Gordon,  I. Irrcher, A.-M. Joseph, S. T. Lowe and A.A. Rungi.  Mitochondrial Biogenesis and the Role of Protein Import in Muscle. Med. Sci. Sport Exerc. 35:86-94, 2003.

Primeau, A., P. Adhihetty and D.A. Hood.  Apoptosis in skeletal and cardiac muscle.  Can. J. Appl. Physiol. 27:349-395, 2002.

Rungi, A.A., A. Primeau, L. Nunes Christie, J.W. Gordon, B.H. Robinson, and D.A. Hood.  Events upstream of mitochondrial protein import limit the oxidative capacity of fibroblasts in multiple mitochondrial disease. Biochim. Biophys. Acta 1586:146-154, 2002.

Hood, D.A., A.A. Rungi, M. Colavecchia, J. W. Gordon and J.J. Schneider.  Stress Proteins and the Mitochondrion. In: Locke, M. and E. Noble (Eds.). Exercise and Stress Response: The Role of Stress Proteins.  CRC Press, New York, Chpt. 7, 2002.

Connor, M.K., I. Irrcher, and D.A. Hood.  Contractile activity‑induced transcriptional activation of cytochrome C involves Sp1 and is proportional to mitochondrial ATP synthesis in C2C12 muscle cells. J. Biol. Chem. 276: 15898‑904, 2001.

Hood, D.A.  Contractile activity-induced mitochondrial biogenesis in skeletal muscle.  J. Appl. Physiol. 90:1137-1157, 2001.

Gordon, J.W., A. A. Rungi, H. Inagaki and D. A. Hood.  Effects of contractile activity on mitochondrial transcription factor A expression in skeletal muscle.  J. Appl. Physiol. 90:389-396, 2001.

Grey, J.Y., M.K. Connor, J.W. Gordon, M. Yano, M. Mori and D.A. Hood.  Tom20-mediated mitochondrial protein import in muscle cells during differentiation.  Am. J. Physiol. Cell Physiol. 279:C1393-C1400, 2000.

Hood, D.A., M. Takahashi, M.K. Connor and D. Freyssenet.  Assembly of the cellular powerhouse:current issues in muscle mitochondrial biogenesis. Ex. Sport Sci. Rev. 28:68-73, 2000.

Connor, M.K., O. Bezborodova, C.P. Escobar and D.A. Hood.  Effect of contractile activity on protein turnover in skeletal muscle mitochondrial subfractions. J. Appl. Physiol. 88: 1601-1606, 2000.

Schneider, J.J. and D.A. Hood. Effect of thyroid hormone on mtHsp70 expression, mitochondrial import and processing in cardiac muscle. J. Endocrinol. 165: 9-17, 2000.


Freyssenet, D., M.K. Connor, M. Takahashi and D.A. Hood.  Cytochrome c transcriptional activation and mRNA stability during contractile activity in skeletal muscle.  Am. J. Physiol. 277 (Endocrinol. Metab.40) E26-E32, 1999.

Freyssenet, D., M. DiCarlo and D.A. Hood.  Calcium-dependent regulation of cytochrome c gene expression in skeletal muscle cells: identification of protein kinase c-dependent pathway.  J. Biol. Chem.  274:9305-9311, 1999.

Freyssenet, D., M. DiCarlo, P. Escobar, J. Grey, J. Schneider and D.A. Hood.  AZT-induced alterations in mitochondrial biogenesis and muscle performance in the rat. Can. J. Physiol. Pharmacol. 77:29-35, 1999.

Craig, E.E., A. Chesley and D.A. Hood.  Thyroid hormone modifies mitochondrial phenotype by increasing protein import without altering degradation.   Am. J. Physiol. 275 (Cell Physiol.44) C1508-C1515, 1998.

Takahashi, M., A. Chesley and D.A. Hood.  Contractile activity-induced adaptations in the mitochondrial protein import system.  Am. J. Physiol. 274 (Cell Physiol.43) C1380-C1387, 1998.

Connor, M.K. and D.A. Hood.  Effect of microgravity on the expression of mitochondrial enzymes in cardiac and skeletal muscle.  J. Appl. Physiol. 84:593-598, 1998.

Hood, D.A. & J.C. McDermott.  Gene expression and signal transduction in striated muscle: a symposium.  Can. J. Appl. Physiol. 23:362-365, 1998.

Craig, E.E. and D.A. Hood. Influence of aging on protein import into cardiac mitochondria.  Am. J. Physiol. (Heart Circul. Physiol. 41) 272:H2983-H2988, 1997.

Takahashi, M. and D.A. Hood.  Protein import into subsarcolemmal and intermyofibrillar skeletal muscle mitochondria: differential import regulation in distinct subcellular regions.  J. Biol. Chem. 271: 27285-27291, 1996.

Connor, M., M. Takahashi, and D.A. Hood.  Tissue-specific stability of nuclear- and mitochondrially-encoded mRNAs.  Arch. Biochem. Biophys. 333:103-108, 1996.

Rezvani, M., O.I. Ornatsky, M.K. Connor, H.A. Eisenberg  and D.A. Hood.  Dystrophin, vinculin and aciculin in skeletal muscle subject to chronic muscle use and disuse.  Med. Sci. Sport Exerc. 28:79-84, 1996.

Ornatsky, O.I., M.K. Connor and D.A. Hood.  Expression of stress proteins and mitochondrial chaperonins in chronically stimulated skeletal muscle.  Biochem. J. 311:119-123, 1995.

Nishio, M.L., O.I Ornatsky, E.E. Craig and D.A. Hood.  Mitochondrial biogenesis during pressure overload induced cardiac hypertrophy in adult rats.  Can. J. Physiol. Pharmacol. 73:630-637, 1995.

Nishio, M.L., O.I. Ornatsky, and D.A. Hood. Effects of hypothyroidism and aortic constriction on mitochondria during cardiac hypertrophy.  Med. Sci. Sport Exerc. 27:1500-1508, 1995.

Rezvani, M., E. Cafarelli, and D.A. Hood.  Performance and excitability of mdx mouse muscle at 2, 5, and 13 weeks of age.  J. Appl. Physiol. 78:961-967, 1995.

Stevens, R.J., M.L. Nishio, and D.A. Hood.  Cytochrome c and cytochrome c oxidase in normal and hypothyroid rat striated muscle during development.  Mol. Cell. Biochem. 143:119-127, 1995.

Ianuzzo, C.D. and D.A. Hood.  Cellular and Molecular adaptations of the respiratory muscles.  In:  Lenfant, C. (Ed.), The Thorax (2 ed.), New York:  Marcel Dekker, pp. 313-348, 1995.


Hood, D.A. and R.L. Terjung.  Endurance training alters alanine and glutamine release from muscle during contractions.  FEBS Letts. 340:287-290, 1994.

Hood, D.A., A. Balaban, M.K. Connor, E.E. Craig, M.L. Nishio, M. Rezvani, and M. Takahashi.  Mitochondrial biogenesis in striated muscle.  Can. J. Appl. Physiol. 19:12-48, 1994.

Eisenberg, H.A. and D.A. Hood.  Blood flow, mitochondria and performance in skeletal muscle following denervation and reinnervation.  J. Appl. Physiol. 76:859-866, 1994.

Takahashi, M., D.T.M. McCurdy, D.A. Essig and D.A. Hood.  δ-Aminolaevulinate synthase expression in muscle after contractions and recovery.  Biochem. J. 291:219-223, 1993.

Cogswell, A.M. & D.A. Hood.  Biochemical and functional characteristics of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions.  Am. J. Physiol. 264 (Cell Physiol. 33):C383-C389, 1993.

Takahashi, M. & D.A. Hood.  Chronic stimulation-induced changes in cardiolipin, mitochondrial enzymes and performance in rat skeletal muscle.  J. Appl. Physiol.  74:934-941, 1993.

Takahashi, M., A. Rana & D.A. Hood.  Portable electrical stimulator for use in small animals.  J. Appl. Physiol.  74:942-945, 1993.

Hood, D.A., J.-A. Simoneau, A.M. Kelly & D. Pette.  Effect of thyroid status on the expression of metabolic enzymes during chronic stimulation.  Am. J. Physiol. 263 (Cell Physiol. 32):C788-C793, 1992.

Hood, D.A., R. Kelton & M.N. Nishio.  Mitochondrial adaptations to chronic muscle use:  effect of iron deficiency.  Comp. Biochem. Physiol.  101A:597-605, 1992.

Hood, D.A. & R.L. Terjung.  Effect of α-ketoacid dehydrogenase phosphorylation on branched-chain amino acid metabolism in muscle.  Am. J. Physiol. 261 (Endocrin. Metab. 24):E628-E634, 1991.

Hood, D.A. & G. Parent.  Metabolic and contractile responses of rat fast-twitch muscle to 10 Hz stimulation.  Am. J. Physiol. 260 (Cell Physiol. 29):C832-C840, 1991.

Wicks, K.L. & D.A. Hood.  Mitochondrial adaptations in denervated muscle: relationship to muscle performance.  Am. J. Physiol. 260 (Cell Physiol. 29):C841-C850, 1991.

Hood, D.A. Species-specific expression of cytochrome c oxidase subunit III mRNA.  Comp.  Biochem. Physiol. 97B:257-260, 1990.

Hood, D.A. Coordinate expression of cytochrome c oxidase subunit III and VIc mRNAs in rat tissues.  Biochem. J. 269:503-506, 1990.

Hood, D.A. & R.L. Terjung.  Amino acid metabolism during exercise and following endurance training.  Sports Medicine 9:23-35, 1990.

Simoneau, J.A., D.A. Hood & D. Pette.  Species-specific responses in enzyme activities of anaerobic and aerobic energy metabolism to increased contractile activity.  In Taylor, A.W. et al. (eds.), Biochemistry of Exercise VII.  Champaign:  Human Kinetics Pub., 1990.  pp. 95-104.

Hood, D.A., R. Zak & D. Pette.  Coordinate induction of mitochondrial and nuclear cytochrome c oxidase subunit mRNAs by chronic muscle stimulation in the rat.  In:  U. Carraro (ed.).  Sarcomeric and Non-Sarcomeric Muscles:  Basic and Applied Research Prospects for the 90s.  Padova:  CLEUP, 1990.  pp. 379-384.

Hood, D.A. & J.A. Simoneau.  Rapid isolation of total RNA from small animal and human skeletal muscle.  Am. J. Physiol. 256 (Cell Physiol. 25):C1092-C1096, 1989.

Hood, D.A., R. Zak & D. Pette.  Chronic stimulation of rat skeletal muscle induces coordinate increases in mitochondrial and nuclear mRNAs of cytochrome c oxidase subunits.  Eur. J. Biochem. 179:275-280, 1989.

Hood, D.A. & D. Pette.  Chronic, long-term electrostimulation creates a unique metabolic enzyme profile in rabbit fast-twitch muscle.  FEBS Letters 247:471-474, 1989.

Terjung, R.L., & D.A. Hood.  The role of amino acids as a fuel for contractile activity in skeletal muscle.  In:  Benzi, G. (Ed.), London: Libbey Eurotext, vol. 2, pp. 251-261, 1989.

Tullson, P.C., H.B. John-Alder, D.A. Hood & R.L. Terjung.  De novo synthesis of adenine nucleotides in different skeletal muscle fiber types.  Am. J. Physiol. 255 (Cell Physiol. 24):C271-C277, 1988.

Hood, D.A. and R.L. Terjung.  Leucine metabolism in perfused rat skeletal muscle during contractions.  Am. J. Physiol. 253 (Endocrinol. Metab. 16):E636-E647, 1987.

Hood, D.A. and R. L. Terjung.  Effect of endurance training on leucine metabolism in perfused rat skeletal muscle during contractions.  Am. J. Physiol. 253 (Endocrinol. Metab. 16):E648-E656, 1987.

Hood, D.A., J. Gorski and R.L. Terjung.  Oxygen cost of twitch and tetanic isomtetric contractions of rat skeletal muscle.  Am. J. Physiol. 250 (Endocrinol. Metab. 13):E449-E456, 1986.

Gorski, J., D.A. Hood and R.L. Terjung.  Blood flow distribution in the tissues of perfused rat hindlimb preparations.  Am. J. Physiol. 250 Endocrinol. Metab. 13):E441-E448, 1986.

Gorski, J., D.A. Hood, H. Kaciuba-Uscilko and R.L. Terjung.  Effect of muscle stimulation in situ in pregnant rats.  Eur. J. Appl. Physiol. 55:390-394, 1986.

Terjung, R.L., G.A. Dudley, R.A. Meyer, D.A. Hood and J. Gorski.  Purine nucleotide cycle function in contracting muscle.  In:  Saltin, B. (ed.), Biochemistry of Exercise VI.  Champaign:  Human Kinetics Pub., 1986.  pp. 131-147.

Terjung, R.L. and D.A. Hood.  Biochemical adaptations in skeletal muscle induced by exercise training.  In Layman, D.K. (Ed.), Nutrition and Aerobic Exercise, Washington:  Am. Chem. Soc. Symposium Series 294: 8-26, 1986.

Gorski, J., D.A. Hood, O.M. Brown and R.L. Terjung.  Incorporation of 15N-leucine amine into ATP of fast-twitch muscle.  Biochem. Biophys. Res. Comm. 128:1260, 1985.

Bonen, A., D.A. Hood, M.H. Tan, M.M. Sopper and N. Begin-Heick.  Insulin binding in human skeletal muscle.  Biochem. Biophys. Acta. 801: 171-176, 1984.

Tan, M.H., A. Bonen, W. Watson-Wright, D.A. Hood, M. Sopper, D. Currie, A.N. Belcastro and G.N. Pierce.  Muscle glycogen repletion after exercise in trained normal and diabetic rats.  J. Appl. Physiol. Respirat. Environ. Exercise Physiol. 57:1404-1408, 1984.Hood DA